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CCPN Conference 2019

4-6 September 2019, hosted by the Leicester Institute of Structural and Chemical Biology (LISCB)

The annual CCPN meeting aims to present current best practice for all aspects of macromolecular NMR and is particularly aimed at PhD students and Post-docs, mainly in the UK Biomolecular NMR community.

This year's conference will be held at the University of Leicester, where it is being hosted by the Leicester Institute of Structural and Chemical Biology (LISCB) at the John Foster Hall. The conference will start just after lunch on Sept 4th and end just before lunch on Sept 6th. There will also be a CCPN demo/workshop session on Analysis Version 3 on the morning of Sept 4th. As is customary at CCPN conferences, Thursday afternoon is reserved for a walk, giving you the opportunity to engage with the speakers while enjoying some of the nearby countryside. The conference will also include the CCPN Assembly meeting.

En suite accommodation will be available on site and is included in the registration fee for the two nights. Additional accommodation will be available for the night before for a modest cost (subject to availability on a first come, first served basis).

 

Online Registration and Abstract Submission

Online Payment

The registration and abstract submission deadline is Mon 19 August.

 

Sessions and Speakers

Session 1: Sensitivity Enhancement in Biomolecular NMR

Session Chair: Phil Williamson (University of Southampton)

Sensitivity represents a major limitation for the application of NMR in the biosciences. Recently however, a number of technological developments in the fields of liquid-state and solid-state NMR have revolutionised the limits of detection. This session will discuss how these developments are revolutionising how we utilize NMR for a range of methods from metabolomics, through to the study of large biomolecular assemblies and membrane proteins. We are delighted that Tony Watts (University of Oxford) will begin this session by describing some of the approaches he has used in his work with membranes and membrane proteins. Józef Lewanowski (University of Warwick) will then speak to us about the increased use of proton-detection in solid-state NMR. Our third speaker, Matt Goodwin from the University of Bristol, will describe how he has been using a cryo-microprobe within a metabolomics context. Finally, Guido Pintaduda will join us from Lyon to tell us about his work on magic-angle spinning DNP NMR of biomolecular assemblies.

 

Session 2 : NMR-guided Docking

Session Chair: Helen Mott (University of Cambridge)

In this session the speakers will explore how the power of NMR is being utilised in data-driven docking. The session will start with an introduction to HADDOCK, one of the oldest and most widely used docking servers run by the Bonvin lab in Utrecht. Gary Thompson (University of Kent) and Helen Mott (University of Cambridge) will describe the methodology of the approach and also give several examples from their work where HADDOCK has been used. In the next talk, Luca Codutti who works with Theresa Carlomagno at the University of Hannover, will describe their INPHARMA approach, which is used for docking small molecule ligands to a common target. Tobias Madl from the University of Graz will talk about how surface accessibility data from NMR and CS-Rosetta can be combined for structure determination and docking of complexes. Finally, Andreas Lingel from Norvartis will give us an industry perspective on the use of NMR for understanding how small molecules bind to protein targets.

 

Session 3 : Complementary Techniques

Session Chair: Rivka Isaakson (King’s College, London)

At CCPN, no one needs convincing about the power of NMR and many of us also rely on alternative techniques to add value/validation to our data and answer remaining questions. In this session, we are pleased to welcome some exciting speakers who will expand on different ways to complement NMR data and tell us some stories from their own research. First up, Katherine Stott, Director of the Biophysics facility at Cambridge University, will give us an overview of methods that can be used to visualise disorder. She will explain how CD, ITC, AUC, SAXS, luminescence & cross-linking combined to tell her latest research story. Janet Lovett, a URF and lecturer at St Andrews, will give us recent insight into electron paramagnetic spectroscopy and ways in which it can work in concert with NMR. Next we will hear from Helen Walden, Professor of Structural Biology at Glasgow University, who will tell us a story of E3 ligases in Parkinson’s Disease that was elucidated using X-ray crystallography, analytical ultracentrifugation and NMR. Last but not least we look forward to a talk by Jeddidiah Bellamy-Carter on his work improving software for carbene footprinting mass-spectrometry in the group of Neil Oldham at Nottingham University.

 

The speakers will discuss in detail the pros and cons of the different approaches they they are using, and there will be plenty of opportunity for questions.  Through discussion, we hope to come up with new ideas as to how future NMR structural projects might best be tackled.

 

We hope you will be able to join us!