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CCPN Conference 2018

6-8th September, University of Kent, Canterbury, Kent

The yearly CCPN meeting aims to present current best practice for all aspects of macromolecular NMR and is particularly aimed at PhD students and Post-docs, mainly in the UK Biomolecular NMR community.  

This year's topics are

  • Ultra High Field NMR 1GHz and beyond
  • Technical aspects of biomolecular NMR
  • Protein-Protein and Protein-Ligand complexes
  • Integrative Structural Biology Conjoined EM and NMR Studies
  • Special 1 Day Symposium with CCPEM. Morning: NMR & Cryo EM Integrated Structural Biology. Afternoon: EM the ‘Resolution Revolution’

 

Speakers include

  • Enrico Luchinat
  • Martin Blackledge
  • Michele Vendruscolo
  • Sebastian Hiller
  • Elena Orlova


The speakers will discuss in detail the pros and cons of the different approaches they they are using, and there will be plenty of opportunity for questions.  Through discussion, we hope to come up with new ideas as to how future NMR structural projects might best be tackled.

This year the conference is at the University of Kent. The conference starts with registration and a buffet lunch on Thursday 6th September, with the first talks that day after lunch with an introduction by Brian Smith. The conference ends with the closing remarks on Saturday 8th after the closing remarks at 16:30. As is customary at CCPN conferences, Friday afternoon is reserved for a walk, giving you the opportunity to engage with the speakers while enjoying the Kent countryside.

Sessions

This year's provisional program will include the following sessions:

Technical aspects of biomolecular NMR (Chair: Fred Muskett, University of Leicester)

  • Hari Arthanari (Dana Farber Cancer Institute, Harvard University): Leveraging the slow relaxation property of the 15N nuclei using multidimensional 15N-detected experiments: For IDPs and beyond.
  • Harry Mackenzie (UCB): 13C-detected NMR experiments for the characterisation of arginine side-chains in solution.
  • Enrico Luchinat (CERM, University of Florence): Protein expression in human cells for in-cell NMR.
  • Martin Blackledge (Institut de Biologie Structurale, Grenoble): Complex Dynamics and Dynamic Complexes: NMR of Highly Dynamic Biomolecules and their Functional Mechanisms.

 

Protein-ligand interactions (Chair: Ben Goult, University of Kent)

  • Brian Smith (University of Glasgow): Introduction to Protein-Protein & Protein - Ligand Interactions by NMR & detecting monovalent cation binding sites.
  • Jennifer Tomlinson (University of Leeds): The target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance.
  • (TBC)
  • Józef Lewandowski (University of Warwick): Characterisation of protein-protein interfaces in large complexes by solid state NMR solvent paramagnetic relaxation enhancements.

 

Integrated structural biology with cryo-EM and NMR (Chair: Gary Thompson, University of Kent)

  • Michele Vendruscolo (University of Cambridge): Determination of protein structural ensembles using NMR and Cryo-EM.
  • Marielle Walti (Laboratory of Chemical Physics, NIDDK): Structural investigation of the interaction of a chaperone with amyloidogenic peptides by NMR and EM.
  • Sebastian Hiller (The Center for Molecular Life Sciences, University of Basel): Functional aspects of the innate immune response studied by integrated structural biology.
  • Diego Gauto (Institut de Biologie Structurale, Grenoble): Structure determination of a half-megadalton aminopeptidase enzyme complex from an integrated NMR and cryo-EM approach.

 

EM biological science (in collaboration with CCP-EM) (Chair: Tom Burnley, CCP-EM / STFC)

  • Elena Orlova (Birkbeck): Cryo EM: Challenges, Achievements, and Prospects (TBC)
  • Rebecca Thompson (University of Leeds): Cryo-EM - From Sample to Structure
  • Ana Casañal​ (MRC-LMB): Architecture of eukaryotic mRNA 3′-end processing machinery: an example of high resolution cryoEM structure determination

There is also a CCPN Analysis v3 Workshop the morning of the 6th.

Directions to the University of Kent campus here.

 

This year the conference is sponsored by: britishbiophysics.org.uk